Based on that opinion, I had no second thoughts when I chose Node.js to rebuild LeasingSH.ro, a well-known repossessed car sales website in Romania. It's not a large project but it's exactly the kind of generic web project we're talking about here:
One of the advantages of using Node.js is that we can probably handle more traffic than we'll ever get. Also, our response time improved significantly, despite the fact that we're still only using a single web instance:
The codebase also became more readable and maintainable, because using a new technology indirectly brings new habits (versus the old PHP), such as using BitBucket for source-control, a cleaner separation of concerns - mostly due to using Jade templates, efficient client-side asset packaging and compression with ASPAX.
As a conclusion, I'd like to see more generic web projects built on Node.js. Too many of those are still powered by PHP. Don't get me wrong, I've used PHP for years and I'm not against it, but sometimes we have to look up to the future.