pointer-events CSS property will allow you to control under what circumstances (if any) a particular graphic element can become the target of mouse events. (<a href="https://developer.mozilla.org/en/CSS/pointer-events/">source</a>).
This is a great way to build CSS tooltips that hide when moused over.
/* Prevents .tooltip from receiving pointer events. */
<a href="http://jsfiddle.net/D75pb/">jsFiddle Demo</a>