For some odd reason, font-rendering in Chrome on Windows is slightly poorer than font-rendering in Firefox or IE on Windows 7 by default. I tried fixing the issue with several different CSS properties to no avail. Low and behold, it was a system/browser issue for me.
Here is how I fixed it:
Enabled ClearType with the default settings. Go to Control Panel > Appearance and Personalization > Display > Adjust ClearType text (on the left). Check the box entitled “Turn on ClearType.” After going through a short wizard, this will fix some of the text rendering issues in Chrome.
Enable "Disable accelerated 2D Canvas" in Chrome. This seems very counterintuitive, but if your graphics card does not have this capability, then vector objects in Chrome render poorly.
Some have indicated that upgrading the drivers for your video card have also resolved the issue, but this seemed to be the only thing that worked for me.